SLEEP NO MORE DURATION TRIAL

Patients who underwent elective laparoscopic myomectomy under total intravenous anesthesia between October 2018 and January 2019 in our hospital, aged 18–60 years, American society of anaesthesiologists (ASA) grade I or II, Body mass index of 18.5–28 kg/m 2, were included in the study.Įxclusion criteria were: patients who have combined ovarian diseases or underwent ovarian surgeries, diabetes mellitus, a preoperative Pittsburgh sleep quality index (PSQI) score of ≥ 6 points, on long-term use of sedative drugs, hypnotics, and psychotropic drugs, on recent night shifts, flying across time zones, having an irregular lifestyle, patients who are unable to communicate due to mental illness or hearing, visual impairment, etc., and patients with sleep apnea syndrome. This study is a prospective, randomized, control study, approved by the ethics committee of General hospital of Ningxia Medical University (approval number: 2018–247), and signed an informed consent form with the patient or his family. This study aimed to observe the effects of morning and afternoon surgeries on the early postoperative sleep function in patients undergoing general anesthesia. It is not clear whether the early postoperative sleep function and the quality of postoperative recovery of patients undergoing general anesthesia are affected by morning and afternoon surgeries. It aggravates postoperative pain and postoperative fatigue, increasing postoperative delirium and cardiovascular adverse events and even cause accidental death of patients. It mainly includes a decrease in total sleep duration, disappearance of rapid eye movement sleep, a significant decrease in slow-wave sleep, a significant increase in light sleep, an increase in the number of awakenings, and highly fragmented sleep. Patients are prone to changes in sleep pattern and overall quality of sleep after surgery, which is called postoperative sleep disturbances (POSD). The circadian rhythm is an internal timing mechanism that is generated by the body to adapt to the external environment, which is closely related to the sleep–wake cycle of humans. Registered 24 September 2019-Retrospectively registered, NCT04103528.

SLEEP NO MORE DURATION TRIAL

Trial registrationĬlinicalTrials, NCT04103528. Conclusionīoth morning and afternoon surgeries have significant impacts on the sleep function in patients undergoing general anesthesia, while afternoon surgery has a more serious impact on sleep function. There were no significant differences between the two groups in the levels of postoperative blood glucose and pain. Compared with those in group A, the level of melatonin on 1 d after surgery in group P was significantly decreased, and the level of cortisol in group P was significantly increased. Compared with group A, the total sleep duration under BIS monitoring in group P was significantly shorter, the sleep efficiency and the overall quality of sleep was significantly reduced ( P < 0.01). The incidence of postoperative sleep disturbances (70.0%) in group P was significantly higher than that in group A (37.9%) ( P < 0.05). The postoperative AIS scores in group P increased significantly compared with those in group A ( P < 0.01). In group P, the sleep induction and the physical and mental functioning during the day scores increased significantly after surgery compared with preoperative scores ( P < 0.05).

The total AIS score, overall quality of sleep, total sleep duration, and final awakening earlier than desired scores of the two groups of patients on the first night after surgery were significantly increased compared with preoperative scores ( P < 0.01). Plasma concentrations of melatonin and cortisol at 6:00 am 1 day before surgery, 1 day after surgery were measured by ELISA, and rapid random blood glucose was measured. The bispectral Index assessed the patient’s total sleep duration, sleep efficiency, and overall quality of sleep from 21:00 to 6:00 on the first night after surgery. The incidences of sleep disturbance one day after the operation in two groups were compared. A total score of > 6 was regarded as postoperative sleep disturbance. The sleep conditions of the two groups of patients were evaluated by the Athens Insomnia Scale (AIS) one day before and one day after the operation. These patients were divided into two groups according to the start time of anesthesia: morning surgery group (group A, 8:00–12:00) and afternoon surgery group (group P, 14:00–18:00). Methodsįifty nine patients, aged 18–60 years, American society of anaesthesiologists (ASA) grade I or II, Body mass index of 18.5–28 kg/m 2, undergoing laparoscopic myomectomy under total intravenous anesthesia, were included in the study. This study aimed to investigate the effects of morning and afternoon surgeries on the early postoperative sleep function in patients undergoing general anesthesia.

Sleep no more duration